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Mast cells make and store histamine (thus antihistamines), plus many other chemical mediators. On the surface of these cells are receptors for Immunoglobulin E, or IgE, which is a protein against foreign proteins like pollen. It is also called an antibody.
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Centre for Developmental Disability HealthMonash Alfred Psychiatry Research Centre (MAPrc)Australian and New Zealand Intensive Care Research Centre (ANZIC RC)After completing a Bachelor of Science Degree at Monash University I undertook an Honours year in the Interferon Laboratory, Department of Biochemistry and Molecular Biology under the supervision of Dr Stephen Ralph. The focus of my PhD study involved the investigation of the components in interferon signaling pathway and the elucidation of the mechanism underlying the resistance of melanoma to interferon treatment. After my PhD, I worked as a postdoctoral fellow with Prof Andy Choo at Murdoch Childrens Research Institute to study chromosome biology.
In many tumor types the promoters of the miR 34a and the miR 34b genes are subject to inactivation by CpG methylation. MiR 34a resides on 1p36 and is commonly deleted in neuroblastomas. Furthermore, the loss of miR 34 expression has been linked to resistance against apoptosis induced by p53 activating agents used in chemotherapy.